Protein Degradation through Ubiquitination – Oxford University Press (2014)
What happens when a protein is “done” and must be taken care of? The companion animation to the Oxford University Press text book Molecular Biology- Principles of Genome Function, encapsulates the basics of ubiquitination through E1>E2>E3 cascade and the molecular components involved. Ubiquitin is a small protein that can be covalently linked to lysine residues of proteins targeted for degradation by proteosomes inside the cell. E1 activating enzyme E2 conjugating enzyme E3 ligase complex The combinatorial diversity of E3 complexes […]
















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